Gluconolactone is a type of a polyhydroxy acid (PHA) that hydrates skin and acts as a very gentle exfoliant which turns it the best ally for those who want to achieve a flawless and smooth skin complexion.
What is gluconolactone
Gluconolactone is a polyhydroxy acid (PHA) derived from gluconic acid, polyhydroxy acids are a type of chemical exfoliants that tend to be gentler than BHA and AHA acids like salicylic acid or glycolic acid for example.
Unlike other types of acids, gluconolactone offers a very gentle skin exfoliation (it’s gentler because it’s a large molecule compared with other types of acids and it does not penetrate the skin deeper than other more powerful acids) at the same time it acts as a skin humectant.
At this point you may have noticed gluconolactone is not as powerful as other active ingredients, but it will be worthy to choose some products that includes it since it can be helpful if you want to achieve better results and to support your skin.
It increases skin hydration and improves skin barrier
Several studies (study) have concluded that gluconolactone and other PHAs offer moisturization and humectant skin properties supporting stratum corneum function. Furthermore they are safe to use on sensitive skin since they are gentle enough.
Unlike AHAs, PHAs like gluconolactone don’t tend to cause skin irritation and they can help skin barrier increasing its ability to support chemical challenge.
Gluconolactone reduces acne as much as benzoyl peroxide
A 1992 study compared the efficacy of a 14% gluconolactone solution vs placebo vs a 5% of benzoyl peroxide.
The study concluded that both gluconolactone and benzoyl peroxide reduces the number of inflammatory and non-inflammatory acne lessons with no significant differences between both compared to placebo.
The study also mentions that patients who used gluconolactone has less side effects than those who used benzoyl peroxide since gluconolactone it’s gentler and suitable for long a term use.
It offers a slightly sun protection and treats photoaging
A 2004 study concluded that gluconolactone provided up to 50% protection against UV radiation in vitro. Furthermore, in a in vivo study it did’t significantly increase sunburn cells in skin.
A neostrata study found that both PHAs and AHAs could treat photodamage and improve skin aging with no significant differences (except in sallowness (AHA 17. 1% and PHA 12.4%) and elasticity in eye contour skin (AHA 13.5% and PHA 10.2% ) after 12 weeks of use.
Gluconolactone acts as an antioxidant
Like most PHAs, gluconolactone also offers antioxidant properties as it functions as a chelating agent so it shows potency in scavenging free radicals.
Gluconolactone has also shown to have anti-glycation effects. Glycation is a process that has shown to deteriorate some structural proteins such as collagen and elastin making it one of the main causes of skin aging.
Gluconolactone side effects
Even though gluconolactone is gentler than other actives, since it is a type of PHA it could have some side effects similar to AHAs and BHAs acids, which includes:
- Skin irritation and itchiness.
- Skin burn.
Although gluconoactone is safe for sensitive skin and it’s very unlikely to cause a side effect, you should always do a patch test before using it in an entire skin area in order to prevent a skin reaction or allergy.